(7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride

Base Information

• Chemical Name: (7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride
• CAS No.: 1287294-69-2
• Molecular Formula: C₂₁H₁₉F₃N₂O₂S*ClH
• Molecular Weight: 456.916

Synonyms:(7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride

Chemical Property of (7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride

There total 7 articles about (7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole (1287375-05-6) → (7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride (1287294-69-2)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; Inert atmosphere;

DOI:10.1016/j.tetasy.2012.10.012

Reference yield:

(7R,10S)-11-tert-butyl 5-((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate (1416007-18-5) → (7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride (1287294-69-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; dichloromethane / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1016/j.tetasy.2012.10.012

Reference yield:

4-bromophenylhydrazine hydrochloride (622-88-8,41931-18-4) → (7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride (1287294-69-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: ethanol / 4 h / Inert atmosphere; Reflux

1.2: 65 h / Inert atmosphere; Reflux

2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / hexane / -5 - 20 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 120 °C / Inert atmosphere

7.1: hydrogenchloride / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

8.1: hydrogenchloride / methanol; dichloromethane / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: |Fischer Indole Synthesis / 1.2: |Fischer Indole Synthesis;

DOI:10.1016/j.tetasy.2012.10.012

upstream raw materials:

(7R,10S)-11-tert-butyl 5-((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

11-tert-butyl 5-(2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

(7R,10S)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole

4-bromophenylhydrazine hydrochloride

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