Cbz-S-3-Aminoisobutyric acid

Base Information

• Chemical Name: Cbz-S-3-Aminoisobutyric acid
• CAS No.: 637337-65-6
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.255
• Hs Code.: 2924299090
• Mol file: 637337-65-6.mol

Synonyms:

Chemical Property of Cbz-S-3-Aminoisobutyric acid

Chemical Property:

• Boiling Point: 435.6±38.0 °C(Predicted)
• PKA: 4.52±0.10(Predicted)
• PSA: 75.63000
• Density: 1.213±0.06 g/cm3(Predicted)
• LogP: 2.02440
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-3-(((Benzyloxy)carbonyl)amino)-2-methylpropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cbz-S-3-Aminoisobutyric acid

There total 10 articles about Cbz-S-3-Aminoisobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[(S)-3-((R)-4-Isopropyl-2-oxo-5,5-diphenyl-oxazolidin-3-yl)-2-methyl-3-oxo-propyl]-carbamic acid benzyl ester → Z-β2hALa-OH (637337-65-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1002/hlca.200390149

Reference yield: 66.0%

(RS)-2-(aminomethyl)propanoic acid hydrochloride (28267-25-6,925704-45-6,132605-98-2) + benzyl chloroformate (501-53-1,94274-21-2) → (2R)-N-benzyloxycarbonyl-2-aminopropanecarboxylic acid (101642-77-7,637337-65-6)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/j.tet.2003.09.062

Reference yield:

DL-3-aminoisobutyric acid (10569-72-9) + benzyl chloroformate (501-53-1,94274-21-2) → (2R)-N-benzyloxycarbonyl-2-aminopropanecarboxylic acid (101642-77-7,637337-65-6)

Guidance literature:

With hydrogenchloride; In sodium hydroxide; diethyl ether; toluene;

upstream raw materials:

diethyl 2-(N-methylphthalimido)-2-methylmalonate

benzyl chloroformate

2-(2'-cyanopropyl)-1H-isoindole-1,3(2H)-dione

(RS)-2-(aminomethyl)propanoic acid hydrochloride

Refernces

• 1、 -. "METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES". Page 258. . Retrieved 2010/02/05.
• 2、 -. "DELTA-AMINO-GAMMA-HYDROXY-OMEGA-ARYL-ALKANOIC ACID AMIDES". . . Retrieved 2008/06/13.