N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Base Information

Chemical Name:N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide
CAS No.:103293-99-8
Molecular Formula:C₂₂H₂₃N₅O₃
Molecular Weight:405.456
Hs Code.:

Synonyms:N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

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Chemical Property of N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

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Technology Process of N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

There total 12 articles about N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.8%

: 103311-39-3
1,4-dihydro-N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

: 103293-99-8
N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Guidance literature:: With manganese(IV) oxide; In chloroform; for 1h; Heating;
DOI:10.1248/cpb.40.2423

Reference yield:

: 103293-96-5
6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid

: 108-00-9
N,N-dimethylethylenediamine

: 103293-99-8
N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 103293-99-8
N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92.8 percent / acetic acid, piperidine / benzene / 2.5 h / Heating

2: 31.8 percent / Et₃N / butan-1-ol / 1 h / Heating

3: 28.8 percent / MnO₂ / CHCl₃ / 1 h / Heating

With piperidine; manganese(IV) oxide; acetic acid; triethylamine; In chloroform; butan-1-ol; benzene;
DOI:10.1248/cpb.40.2423