N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride

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Chemical Name:N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride
CAS No.:881678-54-2
Molecular Formula:C₁₉H₁₉FN₂O₂S*ClH
Molecular Weight:394.897
Hs Code.:

Synonyms:N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride

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Technology Process of N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride

There total 8 articles about N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 881673-43-4
5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carbaldehyde

: 593-51-1
methylamine hydrochloride

: 881678-54-2
N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride

Guidance literature:: With sodium cyanoborohydride; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2017.04.014

Reference yield: 69.0%

: 881678-54-2
N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride

Guidance literature:: With methanol; sodium cyanoborohydride; at 10 - 35 ℃; for 18h;

Reference yield:

: 53631-18-8
2-bromo-1-(3-fluorophenyl)ethanone

: 881678-54-2
N-methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / 0.75 h / 40 - 45 °C

1.2: 1 h / 40 - 45 °C

2.1: hydrogenchloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 760.05 Torr

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 1.5 h / 0 - 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C

6.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / acetonitrile / 1 h / 20 °C / Molecular sieve

7.1: sodium cyanoborohydride / tetrahydrofuran / 20 h / 20 °C

With hydrogenchloride; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2017.04.014