N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

Base Information

Chemical Name:N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide
CAS No.:1224715-83-6
Molecular Formula:C₂₃H₂₅NO₄
Molecular Weight:379.456
Hs Code.:

Synonyms:N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

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Chemical Property of N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

Chemical Property:

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Technology Process of N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

There total 6 articles about N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 712313-61-6
(4-(cyclopropylmethoxy)phenyl)methanol

: 1224717-16-1
N-[1-(5-hydroxy-1-benzofuran-2-yl)ethyl]acetamide

: 1224715-83-6
N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

Guidance literature:: (4-(cyclopropylmethoxy)phenyl)methanol; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 0.5h;

N-[1-(5-hydroxy-1-benzofuran-2-yl)ethyl]acetamide; With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: C₁₆H₂₅NO₂Si

: 1224715-83-6
N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 0.17 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

3.2: 70 °C

With thionyl chloride; tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1224717-13-8
1-(5-{[tert-butyl(dimethyl)silyl]oxy}-1-benzofuran-2-yl)ethanol

: 1224715-83-6
N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.1: sodium azide / N,N-dimethyl-formamide / 20 °C

3.1: triphenylphosphine; water / tetrahydrofuran / 50 °C

4.1: ethyl acetate / 0.17 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: thionyl chloride / N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

6.2: 70 °C

With thionyl chloride; sodium azide; tetrabutyl ammonium fluoride; water; triethylamine; triphenylphosphine; N,N-dimethyl-formamide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;