[4-(cyclopropylmethoxy)phenyl]methanol

Base Information

• Chemical Name: [4-(cyclopropylmethoxy)phenyl]methanol
• CAS No.: 712313-61-6
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol file: 712313-61-6.mol

Synonyms:[4-(cyclopropylmethoxy)phenyl]methanol;4-(cyclopropylmethoxy)benzenemethanol

Chemical Property of [4-(cyclopropylmethoxy)phenyl]methanol

Chemical Property:

• PSA: 29.46000
• LogP: 1.96770

Purity/Quality:

99% ^*data from raw suppliers

[4-(cyclopropylmethoxy)phenyl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-(cyclopropylmethoxy)phenyl]methanol

There total 2 articles about [4-(cyclopropylmethoxy)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(cyclopropylmethoxy)benzaldehyde (164520-99-4) → (4-(cyclopropylmethoxy)phenyl)methanol (712313-61-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;

DOI:10.1002/ejoc.201501486

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (4-(cyclopropylmethoxy)phenyl)methanol (712313-61-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / Reflux

2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

With sodium tetrahydroborate; potassium carbonate; In methanol; acetone;

DOI:10.1002/ejoc.201501486

Reference yield: 88.0%

(4-(cyclopropylmethoxy)phenyl)methanol (712313-61-6) + (E)-3,4,5-trimethoxy-cinnamic acid (20329-98-0,20329-99-1,90-50-6) → 4-(cyclopropylmethoxy)benzyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Reflux;

DOI:10.1016/j.bioorg.2019.03.006

upstream raw materials:

4-(cyclopropylmethoxy)benzaldehyde

4-hydroxy-benzaldehyde

Downstream raw materials:

1-bromomethyl-4-cyclopropylmethoxybenzene

N-[1-(6-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

N-[1-(5-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-2-yl)ethyl]acetamide

N-[1-(6-{[4-(cyclopropylmethoxy)benzyl]oxy}-1-benzofuran-3-yl)ethyl]acetamide

Refernces

• 1、 Zhao, Zefeng,Bai, Yajun,Xie, Jing,Chen, Xufei,He, Xirui,Sun, Ying,Bai, Yujun,Zhang, Yangyang,Wu, Shaoping,Zheng, Xiaohui. "Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA)ester derivatives". . . Retrieved 2019/05/17.
• 2、 -. "COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF IMIDAZOPYRAZINONES". Page/Page column 89. . Retrieved 2018/05/24.