(5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one

Base Information

Chemical Name:(5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one
CAS No.:940288-04-0
Molecular Formula:C₂₅H₂₄NO₅P
Molecular Weight:449.443
Hs Code.:

Synonyms:(5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one

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Chemical Property of (5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one

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Technology Process of (5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one

There total 3 articles about (5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

: 940288-16-4
(-)-(5R,6S)-1-benzyl-5-hydroxy-6-methyl-5,6-dihydropyridin-2(1H)-one

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 940288-04-0
(5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one

Guidance literature:: With pyridine; at 20 ℃; for 8h;
DOI:10.1016/j.tetlet.2007.03.017

Reference yield:

: 898831-79-3
(3R,4S)-4-[benzyl(2-nitrobenzenesulfonyl)amino]pent-1-en-3-ol

: 940288-04-0
(5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiOH*H₂O; mercaptoacetic acid / dimethylformamide / 4 h / 0 °C

1.2: 75.4 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: 99.7 percent / 2nd generation Grubbs catalyst / CH₂Cl₂ / 8 h / 20 °C

3.1: 93.7 percent / pyridine / 8 h / 20 °C

With pyridine; lithium hydroxide; mercaptoacetic acid; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2007.03.017

Reference yield:

: 940288-15-3
(1S,2R)-N-benzyl-N-(2-hydroxy-1-methylbut-3-enyl)acrylamide

: 940288-04-0
(5R,6S)-1-benzyl-5,6-dihydro-6-methyl-5-diphenylphosphoryloxy-1H-pyridine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 99.7 percent / 2nd generation Grubbs catalyst / CH₂Cl₂ / 8 h / 20 °C

2: 93.7 percent / pyridine / 8 h / 20 °C

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;
DOI:10.1016/j.tetlet.2007.03.017