(2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid

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Chemical Name:(2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid
CAS No.:1056751-39-3
Molecular Formula:C₃₈H₄₀N₂O₄S
Molecular Weight:620.813
Hs Code.:

Synonyms:(2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid

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Chemical Property of (2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid

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Technology Process of (2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid

There total 12 articles about (2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1056751-10-0
(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

: 1056751-39-3
(2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; water; Reflux;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: C₃₃H₃₆N₂O₄S

: 1056751-39-3
(2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

2.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

5.1: lithium hydroxide monohydrate / 1,4-dioxane; water / Reflux

With 18-crown-6 ether; lithium hydroxide monohydrate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: C₃₃H₃₄N₂O₃S

: 1056751-39-3
(2Z,4E)-5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

2: lithium hydroxide monohydrate / 1,4-dioxane; water / Reflux

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017