ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate

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Chemical Name:ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate
CAS No.:1489278-43-4
Molecular Formula:C₃₂H₃₆N₂O₇
Molecular Weight:560.647
Hs Code.:

Synonyms:ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate

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Chemical Property of ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate

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Technology Process of ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate

There total 1 articles about ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 95271-93-5
benzoylaminoacetic acid ethyl ester

: 1489278-43-4
ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield: 82.0%

: 1489278-43-4
ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate

: 1489278-49-0
(S)-ethyl 2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxylate

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 65 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489278-43-4
ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxo-3-phenylpropanoate

: 1489279-14-2
(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: Lawessons reagent / tetrahydrofuran / 2 h / 65 °C

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

3: HATU; 4-methyl-morpholine / dichloromethane / 20 °C

With Lawessons reagent; 4-methyl-morpholine; lithium hydroxide monohydrate; HATU; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017