N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide

Base Information

Chemical Name:N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide
CAS No.:82176-13-4
Molecular Formula:C₄₆H₇₁N₉O₁₀S
Molecular Weight:942.19
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide

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Chemical Property of N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide

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Technology Process of N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide

There total 6 articles about N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 82176-12-3
N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine methyl ester

: 82176-13-4
N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide

Guidance literature:: With hydrazine hydrate; In methanol; N,N-dimethyl-formamide; for 48h;

Reference yield:

: 19746-37-3
N-t-butoxycarbonyl-S-acetamidomethyl-L-cysteine

: 82176-13-4
N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide, 2.) triethylamine / 1.) tetrahydrofuran, -10 - 4 deg C, 19 h, 2.) dimethylformamide, -5 - 20 deg C, 25 h

2: 0.9 g / HCl / dioxane / 0.75 h / 20 °C

3: 1.) HCl, butyl nitrite, 2.) triethylamine / 1.) dimethylformamide, tetrahydrofuran, -20 deg C, 45 min, 2.) 4 - 20 deg C, 54 h

4: 89 percent / hydrazine hydrate / methanol; dimethylformamide / 48 h

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; n-Butyl nitrite; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 82176-10-1
N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valine methyl ester

: 82176-13-4
N-tert-butoxycarbonyl-L-leucyl-O-benzyl-L-tyrosyl-L-leucyl-L-valy-S-(acetamidomethyl)-L-cysteinyl-glycine hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / hydrazine hydrate / dimethylformamide / 48 h / 20 °C

2: 1.) HCl, butyl nitrite, 2.) triethylamine / 1.) dimethylformamide, tetrahydrofuran, -20 deg C, 45 min, 2.) 4 - 20 deg C, 54 h

3: 89 percent / hydrazine hydrate / methanol; dimethylformamide / 48 h

With hydrogenchloride; n-Butyl nitrite; hydrazine hydrate; triethylamine; In methanol; N,N-dimethyl-formamide;