(5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

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Chemical Name:(5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine
CAS No.:1443259-26-4
Molecular Formula:C₁₈H₁₈F₄N₄O₂
Molecular Weight:398.36
Hs Code.:

Synonyms:(5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

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Chemical Property of (5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

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Technology Process of (5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

There total 13 articles about (5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 24100-18-3
2-bromo-3-methoxypyridine

: (5R,6R)-5-(5-amino-2-fluorophenyl)-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

: 1443259-26-4
(5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With sulfuric acid; In isopropyl alcohol; at 80 ℃; for 40h;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1443259-26-4
(5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: Multi-step reaction with 13 steps

1.1: ammonia; ammonium chloride / methanol / 72 h / 20 °C

2.1: hydrogenchloride; acetic acid / water / 16 h / Reflux

3.1: sulfuric acid / 48 h / Reflux

4.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

5.1: sodium hydroxide / water; 1,4-dioxane / pH 10 - 11 / Cooling

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 80 °C

7.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 0.33 h / 20 °C

8.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

8.2: 0.5 h

9.1: acetic acid; zinc / 3 h / 80 °C

10.1: Lawessons reagent / tetrahydrofuran / 4 h / 20 - 60 °C

11.1: ammonia / methanol / 24 h / 80 °C

12.1: sodium azide; copper(l) iodide; sodium carbonate; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 1 h / 110 °C

13.1: sulfuric acid / isopropyl alcohol / 40 h / 80 °C

With Lawessons reagent; hydrogenchloride; copper(l) iodide; thionyl chloride; sodium azide; sulfuric acid; ammonia; sodium hydrogencarbonate; sodium carbonate; ammonium chloride; acetic acid; tetrabutylammonium triphenyldifluorosilicate; sodium hydroxide; N,N`-dimethylethylenediamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1350523-51-1
rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile

: 1443259-26-4
(5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: Multi-step reaction with 12 steps

1.1: hydrogenchloride; acetic acid / water / 16 h / Reflux

2.1: sulfuric acid / 48 h / Reflux

3.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

4.1: sodium hydroxide / water; 1,4-dioxane / pH 10 - 11 / Cooling

5.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 0.33 h / 20 °C

7.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

7.2: 0.5 h

8.1: acetic acid; zinc / 3 h / 80 °C

9.1: Lawessons reagent / tetrahydrofuran / 4 h / 20 - 60 °C

10.1: ammonia / methanol / 24 h / 80 °C

11.1: sodium azide; copper(l) iodide; sodium carbonate; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 1 h / 110 °C

12.1: sulfuric acid / isopropyl alcohol / 40 h / 80 °C

With Lawessons reagent; hydrogenchloride; copper(l) iodide; thionyl chloride; sodium azide; sulfuric acid; ammonia; sodium hydrogencarbonate; sodium carbonate; acetic acid; tetrabutylammonium triphenyldifluorosilicate; sodium hydroxide; N,N`-dimethylethylenediamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;