24100-18-3

Basic information

• Product Name: 2-BROMO-3-METHOXYPYRIDINE
• Synonyms: 2-BROMO-3-METHOXYPYRIDINE;AKOS BBS-00006021;TIMTEC-BB SBB005633;2-BROMO-3-METHOXYPYRIDINE, PURUM, 97%;BROMO-3-METHOXYPYRIDINE;2-BROMO-3-METHOXYPYRIDINE, 98+%;Pyridine,2-bromo-3-methoxy-
• CAS NO: 24100-18-3
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• EINECS: 246-017-9
• Product Categories: blocks;Bromides;Pyridines;Halides;Pyridine;Heterocyclic Compounds;Heterocycles;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Aromatics
• Mol File: 24100-18-3.mol
• Article Data: 20

Chemical Properties

• Melting Point: 45-49 °C(lit.)
• Boiling Point: 233.4 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: White to cream/Crystalline Powder
• Density: 1.53 g/cm³
• Vapor Pressure: 0.0852mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Dichloromethane
• PKA: -0.51±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-3-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-METHOXYPYRIDINE(24100-18-3)
• EPA Substance Registry System: 2-BROMO-3-METHOXYPYRIDINE(24100-18-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 24100-18-3(Hazardous Substances Data)

Usage

Chemical Properties

2-BROMO-3-METHOXYPYRIDINE is Light yellow Cryst

Uses

2-BROMO-3-METHOXYPYRIDINE is used in the preparation of triazolopyrimidine derivatives and analogs as AXL receptor tyrosine kinase function inhibitors.

InChI:InChI=1/C6H6BrNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3

Upstream product

• 6602-32-0 2-bromo-pyridin-3-ol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 109-00-2 3-HYDROXYPYRIDINE 
• 186581-53-3 diazomethane 

Downstream Products

• 76066-07-4 2-bromo-3-methoxy-6-nitropyridine 
• 80827-67-4 4-(3-methoxy-pyridin-2-yl)-piperazine 
• 1138323-22-4 3-amino-5-(3-methoxy-pyridin-2-yl)-benzoic acid methyl ester 
• 558465-98-8 2-[(2,5-Difluorophenyl)-hydroxymethyl]-3-methoxypyridine 
• 93560-55-5 2-iodo-3-methoxy-pyridine 
• 1355656-60-8 4-(4-chlorophenoxy)-3-(3-methoxypyridin-2-yl)benzamide 
• 1355653-92-7 4-(4-chlorophenoxy)-3-(3-methoxypyridin-2-yl)-N-(methylsulfonyl)benzamide 
• 1355656-62-0 4-(4-chlorophenoxy)-3-(3-methoxypyridin-2-yl)benzonitrile 
• 1375005-42-7 (4-methoxyphenyl)-(3-methoxypyridin-2-yl)methanol 
• 955376-51-9 6-methoxyimidazo[1,2-a]pyridine 
• 1100750-16-0 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-ol 
• 1258786-31-0 3-methoxy-2-(toluene-4-sulfonyl)-pyridine 
• 20067-47-4 (3-methoxy-pyridin-2-yl)-diphenyl-methanol 
• 263390-59-6 2-(3-cyanophenoxy)-3-methoxypyridine 

Relevant articles and documents

Preparation method of 2-bromo-3-methoxypyridine

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 2-bromine-3-methoxypyridine, which comprises the following reaction steps: (1) preparation of 2-bromine-3-hydroxypyridine, and (2) preparation of 2-bromine-3-methoxypyridine: cooling the sodium hydroxide aqueous solution to -10 DEG C to 0 DEG C by using an ice salt bath, and dropwise adding liquid bromine within the temperature range, dissolving 3-hydroxypyridine in a sodium hydroxide aqueous solution, dropwise adding the solution into the liquid bromine solution, and keepingthe system temperature at 10-15 DEG C, after dropwise adding, stirring the mixed solution for 2.5-3 hours at room temperature, and then adjusting the pH value to 7 by using acid; and recrystallizing the obtained crude product to obtain the 2-bromo-3-hydroxypyridine. The method has the beneficial effects of mild reaction conditions, short route and high yield.

Iridium(iii) complex-based electrochemiluminescent probe for H2S

Since abnormal levels of hydrogen sulphide (H2S) correlate with various diseases, simple methods for its rapid and sensitive detection are highly required. Herein, we introduce a new electrochemiluminescent probe 1 for H2S based on a cyclometalated iridium(iii) complex. o-(Azidomethyl)benzoate ester groups on the main ligands of probe 1 react selectively with H2S, resulting in cascade reactions involving H2S-mediated reduction and intramolecular cyclization/ester cleavage. With this structural change induced by H2S, the intrinsic electrochemiluminescence (ECL) of 1 decreased greatly due to the unfavourable electron transfer of a tripropylamine (TPA) radical. Probe 1 showed a high ECL turn-off ratio and good selectivity for H2S over various anions and biothiols. The sensing mechanism of H2S was elucidated using1H NMR spectroscopy and MALDI-TOF mass spectrometry analyses.

NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID

A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1, R2 and R3 independently represent a group selected from the group consisting of a hydrogen, hydroxyl group, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, excluding the case where two or more of the substituents R1, R2 and R3 are hydrogen, R4 is a group selected from the group consisting of a hydrogen, hydroxy group, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, and m is an integer of 1 to 4, provided that at least one of R1, R2, R3 and R4 represents a radioactive halogen substituent, and a reagent comprising the same.