7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

Base Information

Chemical Name:7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one
CAS No.:1421319-67-6
Molecular Formula:C₂₀H₂₅FO₄
Molecular Weight:348.415
Hs Code.:

Synonyms:7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

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Chemical Property of 7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

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Technology Process of 7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

There total 5 articles about 7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1374219-14-3
7-iodo-1,4-dioxaspiro[4.5]dec-6-en-8-one

: 1421319-66-5
2-fluoro-6-methoxy-4-pentylphenylboronic acid

: 1421319-67-6
7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol303351y

Reference yield:

: 29578-39-0
1-bromo-3-fluoro-5-methoxybenzene

: 1421319-67-6
7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 6 h / 90 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; sodium carbonate / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; sodium carbonate; potassium carbonate; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; pentane; 3.1: |Suzuki Coupling;
DOI:10.1021/ol303351y

Reference yield:

: 4737-50-2
n-pentylboronic acid

: 1421319-67-6
7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 6 h / 90 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; sodium carbonate / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; sodium carbonate; potassium carbonate; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; pentane; 3.1: |Suzuki Coupling;
DOI:10.1021/ol303351y