(7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Base Information

Chemical Name:(7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol
CAS No.:1421319-65-4
Molecular Formula:C₂₀H₂₉FO₄
Molecular Weight:352.446
Hs Code.:

Synonyms:(7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

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Chemical Property of (7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

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Technology Process of (7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

There total 8 articles about (7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1421319-75-6
C₂₀H₂₇FO₄

: 1421319-65-4
(7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: With RuCl₂-(S)-SDP/(R,R)-DPEN; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 20 ℃; for 12h; under 38002.6 Torr; Inert atmosphere; Glovebox;
DOI:10.1021/ol303351y

Reference yield:

: 1374219-14-3
7-iodo-1,4-dioxaspiro[4.5]dec-6-en-8-one

: 1421319-65-4
(7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; sodium carbonate / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

2: hydrogen; 5%-palladium/activated carbon / ethanol / 12 h / 30 °C / Inert atmosphere

3: hydrogen; RuCl₂-(S)-SDP/(R,R)-DPEN; potassium tert-butylate / isopropyl alcohol / 12 h / 20 °C / 38002.6 Torr / Inert atmosphere; Glovebox

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; RuCl₂-(S)-SDP/(R,R)-DPEN; potassium tert-butylate; hydrogen; sodium carbonate; lithium chloride; In 1,2-dimethoxyethane; ethanol; water; isopropyl alcohol; 1: |Suzuki Coupling;
DOI:10.1021/ol303351y

Reference yield:

: 29578-39-0
1-bromo-3-fluoro-5-methoxybenzene

: 1421319-65-4
(7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 6 h / 90 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; sodium carbonate / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

4.1: hydrogen; 5%-palladium/activated carbon / ethanol / 12 h / 30 °C / Inert atmosphere

5.1: hydrogen; RuCl₂-(S)-SDP/(R,R)-DPEN; potassium tert-butylate / isopropyl alcohol / 12 h / 20 °C / 38002.6 Torr / Inert atmosphere; Glovebox

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; RuCl₂-(S)-SDP/(R,R)-DPEN; potassium tert-butylate; hydrogen; tert.-butyl lithium; sodium carbonate; potassium carbonate; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; isopropyl alcohol; toluene; pentane; 3.1: |Suzuki Coupling;
DOI:10.1021/ol303351y