Synonyms:tributylstannylmagnesium chloride
The research focuses on the synthesis of aminomethyltributyltins through the stannylation of immonium salts using tributylstannylmagnesium chloride. The purpose of this study was to develop a method for producing non-substituted, alpha-substituted, or alpha,beta-disubstituted aminomethyltributyltins, which are valuable intermediates in organic synthesis, particularly for the synthesis of beta-amino alcohols. The reaction's success was found to be independent of the anionic part of the immonium salt, and the method could be extended to stannylation by tributylstannylalkalis. The researchers concluded that this stannylation method is a preferred approach for synthesizing alpha-substituted and alpha,beta-disubstituted aminomethyltrialkyltins, which are generally inaccessible through other routes. The study highlighted the potential of these organotin compounds as important reagents in organic synthesis, especially for the synthesis of beta-amino alcohols and beta-amino ketones, which are significant in the pharmaceutical field.
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