Preparation d'aminomethyltributyletains par stannylation de sels d'immonium au moyen du chlorure de tributylstannylmagnesium. Applications a la synthese de β-aminoalcools

Article abstract of DOI:10.1016/S0022-328X(00)99388-4

Tributylstannylmagnesium chloride reacts with immonium salts and gives nonsubstituted, α-substituted or α,α-disubstituted aminomethyltributyltins.The reaction, which can be extended to stannylation by tributylstannylalkalis, is not affected by the nature of the anionic part of the immonium salt.Transmetallation of aminomethyltributyltins with butyllithium, followed by condensation with carbonyl compounds, provides a regiospecific route to β-aminoalcohols.