(E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Name:(E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:918415-48-2
Molecular Formula:C₂₅H₃₄N₂O₄Si
Molecular Weight:454.641
Hs Code.:

Synonyms:(E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of (E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of (E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

There total 5 articles about (E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 918415-44-8
(E)-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethanol

: 4330-20-5
N-3-benzoylthymine

: 918415-48-2
(E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 168000h;
DOI:10.1080/00397910600908918

Reference yield:

: 918415-40-4
(E)-3-(2-hydroxymethyl-cyclobutylidene)-acetic acid ethyl ester

: 918415-48-2
(E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / imidazole / dimethylformamide / 20 h / 20 °C

2: 97 percent / DIBAL-H / toluene; CH₂Cl₂ / 2 h / -60 °C

3: 60 percent / triphenylphosphine; DIAD / tetrahydrofuran / 168000 h / 20 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Mitsunobu reaction;
DOI:10.1080/00397910600908918

Reference yield:

: 918415-42-6
(E)-3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-acetic acid ethyl ester

: 918415-48-2
(E)-3-benzoyl-1-{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutylidene]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / DIBAL-H / toluene; CH₂Cl₂ / 2 h / -60 °C

2: 60 percent / triphenylphosphine; DIAD / tetrahydrofuran / 168000 h / 20 °C

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene; 2: Mitsunobu reaction;
DOI:10.1080/00397910600908918