2-Amino-3-(pyridin-2-yl)propionic acid

Base Information

• Chemical Name: 2-Amino-3-(pyridin-2-yl)propionic acid
• CAS No.: 17407-44-2
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2933399090
• European Community (EC) Number: 691-348-8
• DSSTox Substance ID: DTXSID60400880
• Nikkaji Number: J2.367.497A
• Mol file: 17407-44-2.mol

Synonyms:17407-44-2;2-Amino-3-(pyridin-2-yl)propionic acid;3-(2-Pyridyl)-DL-alanine;2-amino-3-pyridin-2-ylpropanoic acid;2-Amino-3-(pyridin-2-yl)propanoic acid;17407-39-5;Beta-(2-pyridyl)-dl-alanine;H-BETA-(2-PYRIDYL)-DL-ALA-OH;L-2-Pyridylalanine;(RS)-2-Amino-3-pyridin-2-yl-propionic acid;C3-(2-Pyridyl)-DL-alanine;(2R)-2-amino-3-pyridin-2-ylpropanoic acid;H-L-2PAL-OH 2HCL;3-(2-Pyridyl)-L-alanine dihydrochloride;3-PYRIDIN-2-YLALANINE;MFCD00237827;3-(2'-PYRIDYL)-DL-ALANINE;3-(2-Pyridyl)dL-alanine;L-3-(2-Pyridyl) Alanine;SCHEMBL126508;H-DL-ALA(2-PYRI)-OH;H--(2-Pyridyl)-DL-Ala-OH;DTXSID60400880;PDRJLZDUOULRHE-UHFFFAOYSA-N;-(2-PYRIDYL)-DL-ALANINE;3-PYRIDIN-2-YL-L-ALANINE;H-ALA(2-PYRIDYL)-OH?2HCL;amino-3-(2-pyridyl) propionic acid;MFCD00237828;AKOS000172978;AKOS016843460;2-Pyridinepropanoic acid, alpha-amino-;AB05414;AB05436;AM83721;2-Amino-3-(2-pyridinyl)propanoic acid;2-amino-3-pyridin-2-yl-propionic acid;5-Ethyl-6-isopropylthiomorpholin-3-one;DS-12506;SY057718;(R)-2-Amino-3-(2-pyridyl)propionic acid;(S)-2-Amino-3-(2-pyridyl)propionic acid;CS-0155844;DL-2-Amino-3-(pyridin-2-yl)propanoic acid;FT-0639385;FT-0639386;FT-0648444;FT-0690950;A50249;EN300-170655;H-b-(2-Pyridyl)-DL-Ala-OH (H-DL-2Pal-OH);(2R)-2-AMMONIO-3-PYRIDIN-2-YLPROPANOATE;A874076;2,4-DICHLORO-6-METHYLBENZENESULPHONYLCHLORIDE;2-(3-OXO-CYCLOHEXYL)-MALONICACIDDIMETHYLESTER;2-Amino-3-(pyridin-2-yl)propionic acid, AldrichCPR;(S)-2-AMINO-3-PYRIDIN-2-YL-PROPIONIC ACID 2HCL

Chemical Property of 2-Amino-3-(pyridin-2-yl)propionic acid

Chemical Property:

• Vapor Pressure: 0.000116mmHg at 25°C
• Melting Point: 205.5-206 °C
• Refractive Index: 1.581
• Boiling Point: 322.368 °C at 760 mmHg
• PKA: 1.73±0.10(Predicted)
• Flash Point: 148.763 °C
• PSA: 76.21000
• Density: 1.272 g/cm³
• LogP: 0.73630
• Storage Temp.: Store at 0-5°C
• XLogP3: -2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 161

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-(pyridin-2-yl)propionic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CC(C(=O)O)N

Technology Process of 2-Amino-3-(pyridin-2-yl)propionic acid

There total 3 articles about 2-Amino-3-(pyridin-2-yl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(2-pyridyl)acrylic acid (54495-51-1) → D,L-β-(2-pyridyl)-α-alanine (17407-44-2,17407-39-5,37535-52-7)

Guidance literature:

With ammonium hydroxide; at 120 - 140 ℃;

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → D,L-β-(2-pyridyl)-α-alanine (17407-44-2,17407-39-5,37535-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; pyridine

2: concentrated aqueous NH₃ / 120 - 140 °C

With piperidine; pyridine; ammonium hydroxide;

Reference yield:

(S)-2-amino-3-(pyridin-2-yl)propanoic acid (37535-51-6,17407-39-5,37535-52-7) → D,L-β-(2-pyridyl)-α-alanine (17407-44-2,17407-39-5,37535-52-7)

Guidance literature:

With Pseudomonas putida phenylalanine racemase; Enzymatic reaction;

DOI:10.1002/anie.201311061

upstream raw materials:

(E)-3-(2-pyridyl)acrylic acid

pyridine-2-carbaldehyde

(S)-2-amino-3-(pyridin-2-yl)propanoic acid

Downstream raw materials:

2-(4-Bromo-benzylamino)-3-pyridin-2-yl-propionic acid

2-(4-Chloro-benzylamino)-3-pyridin-2-yl-propionic acid

3-Pyridin-2-yl-2-(3-trifluoromethyl-benzylamino)-propionic acid

Refernces