Technology Process of 1-(2-m-tolylthiazol-4-yl)ethanamine
There total 15 articles about 1-(2-m-tolylthiazol-4-yl)ethanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lipase A from Candida antarctica immobilized on Celite; water;
at 45 ℃;
for 60h;
enantioselective reaction;
DOI:10.1016/j.molcatb.2014.05.007
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: magnesium; iodine / diethyl ether / Reflux; Inert atmosphere
1.2: Cooling with ice; Reflux
2.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 23 °C / Inert atmosphere
3.1: ammonium chloride; zinc / water; ethanol / 4 h / Reflux
4.1: immobilized lipase B from Candida antarctica / acetonitrile / 16 h / 23 °C / Molecular sieve; Resolution of racemate; Enzymatic reaction
5.1: water; lipase A from Candida antarctica immobilized on Celite / 60 h / 45 °C
With
immobilized lipase B from Candida antarctica; diphenyl phosphoryl azide; lipase A from Candida antarctica immobilized on Celite; water; iodine; ammonium chloride; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc;
In
diethyl ether; ethanol; water; toluene; acetonitrile;
1.2: |Grignard Reaction;
DOI:10.1016/j.molcatb.2014.05.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium; iodine / diethyl ether / Reflux; Inert atmosphere
1.2: Cooling with ice; Reflux
2.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 23 °C / Inert atmosphere
3.1: ammonium chloride; zinc / water; ethanol / 4 h / Reflux
4.1: water; acetonitrile; formic acid; diethylamine; methanol / Resolution of racemate
With
diphenyl phosphoryl azide; iodine; ammonium chloride; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc;
In
methanol; formic acid; diethyl ether; ethanol; water; diethylamine; toluene; acetonitrile;
1.2: |Grignard Reaction;
DOI:10.1016/j.molcatb.2014.05.007
