4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

Base Information

Chemical Name:4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine
CAS No.:308245-26-3
Molecular Formula:C₄₉H₅₀N₆O₁₂S₂
Molecular Weight:979.101
Hs Code.:

Synonyms:4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

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Chemical Property of 4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

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Technology Process of 4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

There total 9 articles about 4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid (1S,2S)-3-acetoxy-2-{2-[(6-{2-[(1S,2S)-2-acetoxy-1-acetoxymethyl-2-(4-methylsulfanyl-phenyl)-ethylcarbamoyl]-phenylcarbamoyl}-4-azido-pyridine-2-carbonyl)-amino]-benzoylamino}-1-(4-methylsulfanyl-phenyl)-propyl ester

: 308245-26-3
4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

Guidance literature:: With hydrogen; 10percent Pd/C; In tetrahydrofuran; methanol; at 20 ℃; for 48h; under 760.051 Torr;
DOI:10.1021/ja001225c

Reference yield:

: 71022-75-8
4-chloropyridine-2,6-dicarbonyl dichloride

: 308245-26-3
4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / DMAP; pyridine / CH₂Cl₂ / 16 h / 20 °C

2: sodium azide / dimethylformamide / 48 h / 45 °C

3: H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 48 h / 20 °C / 760.05 Torr

With pyridine; dmap; sodium azide; hydrogen; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja001225c

Reference yield:

: 16854-32-3
(1S,2S)-(+)-thiomicamine

: 308245-26-3
4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP; pyridine / 0 °C

2: pyridine; DMAP / 3 h / 60 °C

3: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol / 48 h / 20 °C / 760.05 Torr

4: 67 percent / DMAP; pyridine / CH₂Cl₂ / 16 h / 20 °C

5: sodium azide / dimethylformamide / 48 h / 45 °C

6: H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 48 h / 20 °C / 760.05 Torr

With pyridine; dmap; sodium azide; hydrogen; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja001225c