6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile

Base Information

Chemical Name:6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile
CAS No.:1196678-18-8
Molecular Formula:C₂₈H₂₉Cl₂N₉
Molecular Weight:562.505
Hs Code.:

Synonyms:6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile

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Chemical Property of 6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile

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Technology Process of 6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile

There total 11 articles about 6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 6-[(2-aminoethyl)amino]-pyridine-3-carbonitrile dihydrochloride

: 1196678-38-2
5-Chloro-2-[1-(cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidine

: 1196678-18-8
6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 33252-28-7
6-chloronicotinonitrile

: 1196678-18-8
6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 130 °C / Microwave irradiation

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 6574-98-7
2,4-dichlorobenzylnitrile

: 1196678-18-8
6-{[2-({2-[1-(Cyclopropylmethyl)piperidin-4-yl]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -70 - -60 °C / Inert atmosphere

1.2: 16.33 h / -70 - 20 °C

2.1: ethanol; sodium / ethanol / 4 h / Reflux

3.1: 1-methyl-pyrrolidin-2-one / 3 h / 150 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

6.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 2.5 h / 120 °C

6.2: pH 7

7.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 130 °C / Microwave irradiation

With hydrogenchloride; n-butyllithium; ethanol; N-benzyl-N,N,N-triethylammonium chloride; sodium; potassium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;