(R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

Base Information

Chemical Name:(R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene
CAS No.:325479-30-9
Molecular Formula:C₁₉H₂₇NO₃Si
Molecular Weight:345.514
Hs Code.:

Synonyms:(R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

Suppliers and Price of (R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

There total 4 articles about (R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 325479-27-4
(4R,1'E)-(-)-3-(3'-oxobut-1'-enyl)-4-phenyloxazolidin-2-one

: 325479-30-9
(R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

Guidance literature:: (4R,1'E)-(-)-3-(3'-oxobut-1'-enyl)-4-phenyloxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo005619y

Reference yield:

: 875-74-1
(R)-phenylglycine

: 325479-30-9
(R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / LiBH₄; trimethylsilyl chloride / tetrahydrofuran / 49 h / 0 - 20 °C

2.1: 90 percent / K₂CO₃ / 2.5 h / 130 °C

3.1: 88 percent / N-methylmorpholine / CH₂Cl₂ / 16 h / 20 °C

4.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

4.2: 76 percent / tetrahydrofuran / -78 - 20 °C

With 4-methyl-morpholine; lithium borohydride; chloro-trimethyl-silane; sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo005619y

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 325479-30-9
(R,E)-3-(tert-butyldimethylsiloxy)-1-(4-phenyl-2-oxazolidinon-3-yl)-1,3-butadiene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / K₂CO₃ / 2.5 h / 130 °C

2.1: 88 percent / N-methylmorpholine / CH₂Cl₂ / 16 h / 20 °C

3.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

3.2: 76 percent / tetrahydrofuran / -78 - 20 °C

With 4-methyl-morpholine; sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo005619y