C₁₇H₁₈N₄

Base Information

• Chemical Name: C₁₇H₁₈N₄
• CAS No.: 1360552-10-8
• Molecular Formula: C₁₇H₁₈N₄
• Molecular Weight: 278.357
• Mol file: 1360552-10-8.mol

Synonyms:C₁₇H₁₈N₄

Chemical Property of C₁₇H₁₈N₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₈N₄

There total 4 articles about C₁₇H₁₈N₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-(4-bromo-phenyl)-2-cyclopropylpropionitrile (1360551-90-1) + 5-bromo-N-methylpyrimidin-2-amine (31402-54-7) → C17H18N4 (1360552-10-8)

Guidance literature:

5-bromo-N-methylpyrimidin-2-amine; With hexamethyldistannane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 115 ℃; for 1h; Inert atmosphere;

(R)-2-(4-bromo-phenyl)-2-cyclopropylpropionitrile; In toluene; at 115 ℃; Inert atmosphere;

Reference yield:

(4-bromophenyl)(cyclopropyl)methanone (6952-89-2) → C17H18N4 (1360552-10-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 2.16 h / -78 - 20 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

2.2: 2 h / -78 - 20 °C

3.1: carbon dioxide / ethanol / Resolution of racemate

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / toluene / 1 h / 115 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.2: 115 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; boron trifluoride diethyl etherate; hexamethyldistannane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene;

Reference yield:

1-(4-bromophenyl)-1-cyclopropylethan-1-ol (56041-75-9) → C17H18N4 (1360552-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

1.2: 2 h / -78 - 20 °C

2.1: carbon dioxide / ethanol / Resolution of racemate

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / toluene / 1 h / 115 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3.2: 115 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; boron trifluoride diethyl etherate; hexamethyldistannane; In ethanol; dichloromethane; toluene;

upstream raw materials:

(4-bromophenyl)(cyclopropyl)methanone

(R)-2-(4-bromo-phenyl)-2-cyclopropylpropionitrile

5-bromo-N-methylpyrimidin-2-amine

1-(4-bromophenyl)-1-cyclopropylethan-1-ol

Downstream raw materials:

(R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine