(S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide

Base Information

• Chemical Name: (S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide
• CAS No.: 1620481-07-3
• Molecular Formula: C₂₉H₃₃N₅O₅
• Molecular Weight: 531.612
• Mol file: 1620481-07-3.mol

Synonyms:(S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide

Chemical Property of (S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide

There total 11 articles about (S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate (1620481-09-5) → (S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide (1620481-07-3)

Guidance literature:

With hydroxylamine potassium salt; In methanol; for 2h;

DOI:10.3109/14756366.2013.827678

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) → (S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide (1620481-07-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.33 h

1.2: 8 h / 20 °C

2.1: hydrogenchloride / ethyl acetate / 5 h / 20 °C

3.1: triethylamine / dichloromethane / 5 h / 20 °C

4.1: hydroxylamine potassium salt / methanol / 2 h

With hydrogenchloride; hydroxylamine potassium salt; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; dichloromethane; ethyl acetate;

DOI:10.3109/14756366.2013.827678

Reference yield:

(S)-2-phenylglycine (2935-35-5) → (S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide (1620481-07-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / methanol; water

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.33 h

2.2: 8 h / 20 °C

3.1: hydrogenchloride / ethyl acetate / 5 h / 20 °C

4.1: triethylamine / dichloromethane / 5 h / 20 °C

5.1: hydroxylamine potassium salt / methanol / 2 h

With hydrogenchloride; hydroxylamine potassium salt; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; dichloromethane; water; ethyl acetate;

DOI:10.3109/14756366.2013.827678

upstream raw materials:

(S)-2-phenylglycine

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

(S)-2-amino-N-benzyl-2-phenylacetamide hydrochloride

(S)-tert-butyl (2-(benzylamino)-2-oxo-1-phenylethyl)carbamate