(S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate

Base Information

• Chemical Name: (S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate
• CAS No.: 1620481-09-5
• Molecular Formula: C₃₀H₃₄N₄O₅
• Molecular Weight: 530.624
• Mol file: 1620481-09-5.mol

Synonyms:(S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate

Chemical Property of (S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate

There total 8 articles about (S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) → (S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate (1620481-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.33 h

1.2: 8 h / 20 °C

2.1: hydrogenchloride / ethyl acetate / 5 h / 20 °C

3.1: triethylamine / dichloromethane / 5 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.3109/14756366.2013.827678

Reference yield:

(S)-2-phenylglycine (2935-35-5) → (S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate (1620481-09-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / methanol; water

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.33 h

2.2: 8 h / 20 °C

3.1: hydrogenchloride / ethyl acetate / 5 h / 20 °C

4.1: triethylamine / dichloromethane / 5 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; dichloromethane; water; ethyl acetate;

DOI:10.3109/14756366.2013.827678

Reference yield:

(S)-tert-butyl (2-(benzylamino)-2-oxo-1-phenylethyl)carbamate (117422-78-3) → (S)-methyl 6-(4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)benzamido)hexanoate (1620481-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 5 h / 20 °C

2: triethylamine / dichloromethane / 5 h / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.3109/14756366.2013.827678

upstream raw materials:

(S)-2-phenylglycine

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

(S)-tert-butyl (2-(benzylamino)-2-oxo-1-phenylethyl)carbamate

4-amino-benzoic acid

Downstream raw materials:

(S)-4-(3-(2-(benzylamino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide