2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

Base Information

Chemical Name:2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid
CAS No.:1402393-85-4
Molecular Formula:C₂₂H₂₉F₃N₆O₅
Molecular Weight:514.505
Hs Code.:

Synonyms:2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

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Chemical Property of 2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

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Technology Process of 2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

There total 2 articles about 2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1402393-79-6
di-tert-butyl 2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

: 1402393-85-4
2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/chem.201200737

Reference yield:

: 1211942-20-9
2-chloro-N-(6-cyano-2-trifluoromethylphenyl)ethanamide

: 162148-48-3
(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

: 1402393-85-4
2,2'-(4-(2-(2-cyano-6-(trifluoromethyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 24 h / 50 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With sodium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1002/chem.201200737