S-2-chlorovaleric acid

Base Information

• Chemical Name: S-2-chlorovaleric acid
• CAS No.: 32644-12-5
• Molecular Formula: C5H9 Cl O2
• Molecular Weight: 136.58
• Hs Code.: 2915900090
• Mol file: 32644-12-5.mol

Synonyms:Valericacid, 2-chloro-, (S)- (8CI)

Chemical Property of S-2-chlorovaleric acid

Chemical Property:

• Boiling Point: 219.3±13.0 °C(Predicted)
• PKA: 2.97±0.20(Predicted)
• PSA: 37.30000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 1.47850

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Chloropentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-2-chlorovaleric acid

There total 18 articles about S-2-chlorovaleric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

L-Norvaline (6600-40-4,498-18-0) → (2S)-2-chloropentanoic acid (32644-12-5)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

DOI:10.1016/j.bmc.2013.11.030

Reference yield: 69.0%

D-norvaline (2013-12-9,498-18-0) → (2R)-2-Chloropentanoic acid (6155-96-0,32644-12-5,94347-45-2,80919-72-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

DOI:10.1016/j.bmc.2013.11.030

Reference yield:

propane (74-98-6) → (2R)-2-Chloropentanoic acid (6155-96-0,32644-12-5,94347-45-2,80919-72-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 4h;

DOI:10.1002/chem.201200990

upstream raw materials:

methyl rac-2-chloropentanoate

D-norvaline

1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyl pentanoate

valeric acid

Downstream raw materials:

(-)-(1'S,3R,6'R)-1-(2,2,6-trimethylcyclohexyl)hexan-3-ol

(+)-(1'R,3R,6'S)-1-(2,2,6-trimethylcyclohexyl)hexan-3-ol

(R)-1-Benzenesulfonyl-1-((1S,6R)-2,2,6-trimethyl-cyclohexyl)-hexan-3-ol

(R)-1-Benzenesulfonyl-1-((1R,6S)-2,2,6-trimethyl-cyclohexyl)-hexan-3-ol