S-2-Chloro-3-methylvaleric acid

Base Information

• Chemical Name: S-2-Chloro-3-methylvaleric acid
• CAS No.: 921-48-2
• Molecular Formula: C₆H₁₁ClO₂
• Molecular Weight: 150.605
• Mol file: 921-48-2.mol

Synonyms:Valericacid, 2-chloro-3-methyl- (7CI,8CI); 2-Chloro-3-methylpentanoic acid;2-Chloro-3-methylvaleric acid

Chemical Property of S-2-Chloro-3-methylvaleric acid

Chemical Property:

• PSA: 37.30000
• LogP: 1.72450

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-2-Chloro-3-methylvaleric acid

There total 8 articles about S-2-Chloro-3-methylvaleric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

L-isoleucine (73-32-5,959215-79-3,18875-42-8) → (2S,3S)-2-chloro-3-methylpentanoic acid (921-48-2,32644-14-7,94318-83-9,94318-84-0,95977-20-1,95977-24-5,32653-34-2)

Guidance literature:

With hydrogenchloride; sodium nitrite; at 0 - 20 ℃; for 4.25h;

DOI:10.1080/15421400590958089

Reference yield: 82.0%

isoleucine (319-78-8,443-79-8,1509-34-8,1509-35-9,3107-04-8,7004-09-3,73-32-5,959215-79-3,18875-42-8) → 1-chloro-2-methylbutanecarboxylic acid (921-48-2)

Guidance literature:

With pyridinium polyhydrogen fluoride; potassium chloride; sodium nitrite; for 72h; Ambient temperature;

DOI:10.1002/hlca.19830660404

Reference yield: 70.0%

L-isoleucine (73-32-5,959215-79-3,18875-42-8) → (2S,3S)-2-chloro-3-methylpentanoic acid (921-48-2,32644-14-7,94318-83-9,94318-84-0,95977-20-1,95977-24-5,32653-34-2)

Guidance literature:

With sodium carbonate; sodium nitrite; In hydrogenchloride; water;

upstream raw materials:

isoleucine

sec-butyl-malonic acid

L-isoleucine

L-isoleucine

Downstream raw materials:

4-[⁽¹⁾-chloro-⁽²⁾-methylbutyl carboxy]-4'-biphenylcarboxyphenylferrocene

(+)-(S)-3-methyl-1-pentene

(3S)-methylvaleric acid

(4S,3'S)-3-(3'-methyl-1'-oxopentyl)-4-benzyl-2-oxazolidinone