2-Formamido-4-methylpentanoic acid

Base Information

• Chemical Name: 2-Formamido-4-methylpentanoic acid
• CAS No.: 5338-45-4
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.185
• Hs Code.: 2924199090
• NSC Number: 334321,3162
• Mol file: 5338-45-4.mol

Synonyms:2-formamido-4-methylpentanoic acid;5338-45-4;N-Formyl-DL-leucine;DL-Leucine, N-formyl-;N-Formylleucine #;2-formamido-4-methyl-pentanoic acid;Formyl-dl-Leucin;NSC-334321;NSC334321;N-Formyl-S-leucine;N-Formylleucine;NSC 334321;SCHEMBL771045;2-formamido-4-methylpentanoicacid;NSC3162;BCP33008;NSC 3162;NSC-3162;MFCD00063283;AKOS009158901;FT-0635983;EN300-1299774;A829553;A829575;A833062;2-Formamido-4-methylpentanoic acid (For-DL-Leu-OH);N-Formyl-Leu-OH;L-Leucine, N-formyl-

Chemical Property of 2-Formamido-4-methylpentanoic acid

Chemical Property:

• PSA: 66.40000
• LogP: 1.25850
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 159.08954328
• Heavy Atom Count: 11
• Complexity: 145

Purity/Quality:

99% ^*data from raw suppliers

2-Formamido-4-methylpentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)NC=O

Technology Process of 2-Formamido-4-methylpentanoic acid

There total 11 articles about 2-Formamido-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formic acid (64-18-6) + L-leucine hydrochloride (760-84-9) → N-formyl-L-leucine (5338-45-4,44978-39-4,89921-44-8,6113-61-7)

Guidance literature:

With cyano-hydroxyimino-acetic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; at 20 ℃; for 3h; Reagent/catalyst; Solvent;

DOI:10.1016/j.tetlet.2013.02.013

Reference yield: 90.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → N-formyl-L-leucine (5338-45-4,44978-39-4,89921-44-8,6113-61-7)

Guidance literature:

With formamide; mercury; In water;

Reference yield: 89.0%

formic acid (64-18-6) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → N-formyl-L-leucine (5338-45-4,44978-39-4,89921-44-8,6113-61-7)

Guidance literature:

With acetic anhydride; at 0 - 5 ℃;

DOI:10.1007/BF00752788

upstream raw materials:

formic acid

(R)-leucine

L-leucine

L-Leucine benzyl ester

Downstream raw materials:

(R)-leucine

L-leucine

2-Bromo-4-methylpentanoic Acid

(S)-4-benzyloxycarbonylamino-2-[(N-formyl-L-leucyl)-amino]-butyric acid

Refernces

• 1、 Chapman, Robert S. L.,Lawrence, Ruth,Williams, Jonathan M. J.,Bull, Steven D.. "Formyloxyacetoxyphenylmethane as an N-Formylating Reagent for Amines, Amino Acids, and Peptides". supporting information. p. 4908 - 4911. Retrieved 2017/09/23.
• 2、 Yang, Peng-Yu,Liu, Kai,Ngai, Mun Hong,Lear, Martin J.,Wenk, Markus R.,Yao, Shao Q.. "Activity-based proteome profiling of potential cellular targets of orlistat - An FDA-approved drug with anti-tumor activities". supporting information; experimental part. p. 656 - 666. Retrieved 2010/03/25.