1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate
CAS No.:1644276-71-0
Molecular Formula:C₁₉H₂₃NO₅
Molecular Weight:345.395
Hs Code.:

Synonyms:1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate

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Chemical Property of 1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate

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Technology Process of 1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate

There total 4 articles about 1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1644276-68-5
methyl (S)-2-[(tert-butoxycarbonyl)amino]-5-oxo-7-phenyl-6-heptynoate

: 1644276-71-0
1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With methanesulfonic acid; In methanol; dichloromethane; at 20 ℃; for 4h; Solvent;
DOI:10.1002/ejoc.201402336

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 1644276-71-0
1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 24 h / 20 °C

2.1: triethylamine; dmap / dichloromethane / 24 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -50 °C

3.2: 3 h / -50 °C

4.1: methanesulfonic acid / methanol; dichloromethane / 4 h / 20 °C

With hydrogenchloride; dmap; n-butyllithium; methanesulfonic acid; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1002/ejoc.201402336

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 1644276-71-0
1-tert-butyl 2-methyl (S,E)-5-(2-oxo-2-phenylethylidene)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / dichloromethane / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -50 °C

2.2: 3 h / -50 °C

3.1: methanesulfonic acid / methanol; dichloromethane / 4 h / 20 °C

With dmap; n-butyllithium; methanesulfonic acid; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1002/ejoc.201402336