N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

Base Information

Chemical Name:N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine
CAS No.:913645-81-5
Molecular Formula:C₄₃H₄₅N₅O₇S₂
Molecular Weight:807.992
Hs Code.:

N<sup>6</sup>-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

Synonyms:N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

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Technology Process of N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

There total 5 articles about N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 913645-80-4
N⁶-benzoyl-2'-O-(tert-butyldithiomethyl)adenosine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 913645-81-5
N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1021/ja0636587

Reference yield:

: toluene-4-thiosulfonic acid S-[2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxymethyl] ester

: 913645-81-5
N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂; dimethylformamide / 0.5 h / 20 °C

1.2: 10.33 g / NH₄F / methanol / 16 h / 20 °C

2.1: 91 percent / pyridine / 2 h / 20 °C

With pyridine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0636587

Reference yield:

: 79154-57-7
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

: 913645-81-5
N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldithiomethyl)adenosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: AcOH; Ac₂O / 48 h / 20 °C

1.2: K₂CO₃; water

2.1: Et₃N; 3 Angstroem MS; SO₂Cl₂ / CH₂Cl₂ / 1 h

2.2: CH₂Cl₂; dimethylformamide / 0.5 h / 20 °C

3.1: CH₂Cl₂; dimethylformamide / 0.5 h / 20 °C

3.2: 10.33 g / NH₄F / methanol / 16 h / 20 °C

4.1: 91 percent / pyridine / 2 h / 20 °C

With pyridine; sulfuryl dichloride; 3 Angstroem MS; acetic anhydride; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0636587