(S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

Base Information

Chemical Name:(S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate
CAS No.:1402822-34-7
Molecular Formula:C₂₃H₃₀N₅O₉P
Molecular Weight:551.493
Hs Code.:

(S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

Synonyms:(S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

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Chemical Property of (S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

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Technology Process of (S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

There total 6 articles about (S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1402822-33-6
(2S)-isopropyl2-(((S)-((1R)-1-((3aR,4S,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-cyano-2-methoxytetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

: 1402822-34-7
(S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: With formic acid; In water; for 0.333333h;

Reference yield:

: 1402821-81-1
(2R,3R,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-5-((R)-1-hydroxyethyl)tetrahydrofuran-2-carbonitrile

: 1402822-34-7
(S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / 1,4-dioxane / 1.5 h / 20 °C

2.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / Inert atmosphere

2.2: 0.33 h / 50 °C / Inert atmosphere

3.1: formic acid / water / 0.33 h

With formic acid; tert-butylmagnesium chloride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1402822-34-7
(S)-isopropyl2-(((S)-((R)-1-((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / -10 - -3 °C

1.2: 20 °C / Cooling

2.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / Inert atmosphere

2.2: 0.33 h / 50 °C / Inert atmosphere

3.1: formic acid / water / 0.33 h

With formic acid; tert-butylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane; water;