3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile

Base Information

Chemical Name:3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile
CAS No.:182368-66-7
Molecular Formula:C₁₉H₂₅N₃O₂
Molecular Weight:327.426
Hs Code.:

Synonyms:3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile

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Chemical Property of 3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile

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Technology Process of 3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile

There total 4 articles about 3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 107-13-1,25014-41-9
acrylonitrile

: 182128-10-5
(S)-1-(2-Bromo-benzoyl)-2-tert-butyl-3-methyl-tetrahydro-pyrimidin-4-one

: 139119-52-1
1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one

: 182368-66-7
3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium cyanoborohydride; In toluene; Heating;
DOI:10.1021/ja961484v

Reference yield:

: 138723-46-3
(S)-2-tert-butyl-1-carbobenzyloxy-2,3-dihydro-4(1H)-pyrimidinone

: 182368-66-7
3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / H₂ / Pd/C / 26252.1 Torr / Ambient temperature

2: Et₃N / tetrahydrofuran

3: NaH / tetrahydrofuran

4: 59 percent / Bu₃SnCl, NaCNBH₃, AIBN / toluene / Heating

With 2,2'-azobis(isobutyronitrile); tributyltin chloride; hydrogen; sodium hydride; sodium cyanoborohydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; toluene;
DOI:10.1021/ja961484v

Reference yield:

: 182128-24-1
(R)-2-tert-Butyl-tetrahydro-pyrimidin-4-one

: 182368-66-7
3-((2S,4S)-3-Benzoyl-2-tert-butyl-1-methyl-6-oxo-hexahydro-pyrimidin-4-yl)-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran

2: NaH / tetrahydrofuran

3: 59 percent / Bu₃SnCl, NaCNBH₃, AIBN / toluene / Heating

With 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium hydride; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/ja961484v