(E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide

Base Information

• Chemical Name: (E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide
• CAS No.: 1246852-15-2
• Molecular Formula: C₂₂H₂₇NO₄
• Molecular Weight: 369.461
• Mol file: 1246852-15-2.mol

Synonyms:(E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide

Chemical Property of (E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide

There total 1 articles about (E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-tert-butyl ethyl ferulate + tyramine hydrochloride (60-19-5) → (E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide (1246852-15-2)

Guidance literature:

3-tert-butyl ethyl ferulate; With 1-hydroxy-pyrrolidine-2,5-dione; In acetonitrile; for 0.0833333h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; for 24h; Cooling with ice;

tyramine hydrochloride; With triethylamine; In acetonitrile; at 20 ℃; for 7h;

DOI:10.1002/cjoc.201500054

Reference yield: 42.0%

(E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide (1246852-15-2) → C44H52N2O8 + C44H52N2O8

Guidance literature:

With iron(III) chloride hexahydrate; In water; acetone; at 20 ℃; for 41h; Inert atmosphere;

DOI:10.1002/cjoc.201500054

Reference yield: 12.0%

(E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide (1246852-15-2) → C44H52N2O8

Guidance literature:

With copper(II) nitrate trihydrate; In ethanol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/cjoc.201500054

upstream raw materials:

tyramine hydrochloride

Downstream raw materials:

(±)-canabisin D