N-phenyl-4-trifluoromethylacetanilide

Base Information

• Chemical Name: N-phenyl-4-trifluoromethylacetanilide
• CAS No.: 53451-85-7
• Molecular Formula: C₁₅H₁₂F₃NO
• Molecular Weight: 279.262
• Mol file: 53451-85-7.mol

Synonyms:N-phenyl-4-trifluoromethylacetanilide

Chemical Property of N-phenyl-4-trifluoromethylacetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenyl-4-trifluoromethylacetanilide

There total 4 articles about N-phenyl-4-trifluoromethylacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bis(4-(trifluoromethyl)phenyl)iodonium trifluoromethanesulfonate (871362-15-1) + Acetanilid (103-84-4) → N-phenyl-4-trifluoromethylacetanilide (53451-85-7)

Guidance literature:

With sodium hydride; In toluene; mineral oil; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01079

Reference yield: 31.0%

4-(trifluromethyl)acetanilide (349-97-3) + phenylboronic acid (98-80-6) → N-phenyl-4-trifluoromethylacetanilide (53451-85-7)

Guidance literature:

With ammonium cerium (IV) nitrate; caesium carbonate; In acetonitrile; at 20 ℃; for 40h; Sealed tube; Irradiation;

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) → N-phenyl-4-trifluoromethylacetanilide (53451-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid; boron trifluoride diethyl etherate / dichloromethane / 1 h / 20 °C

1.2: 0.25 h / 20 °C

2.1: sodium hydride / toluene; mineral oil / 24 h / 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene; mineral oil;

DOI:10.1021/acs.orglett.5b01079

upstream raw materials:

bromobenzene

4-(trifluromethyl)acetanilide

bis(4-(trifluoromethyl)phenyl)iodonium trifluoromethanesulfonate

Acetanilid

Downstream raw materials:

4-phenylaminobenzoic acid

phenyl(4-trifluoromethylphenyl)amine

Refernces

• 1、 -. "Method for preparing N,N-diarylamide derivatives". Paragraph 0032-0034. . Retrieved 2019/02/04.