1-(Chloromethyl)-2,4-dimethoxybenzene

Base Information

Chemical Name:1-(Chloromethyl)-2,4-dimethoxybenzene
CAS No.:55791-52-1
Molecular Formula:C9H11ClO2
Molecular Weight:186.638
Hs Code.:2909309090
DSSTox Substance ID:DTXSID20594254
Wikidata:Q82489039
Mol file:55791-52-1.mol

Synonyms:55791-52-1;1-(chloromethyl)-2,4-dimethoxybenzene;2,4-Dimethoxybenzylchloride;1-(Chloromethyl)-2,4-dimethoxy-benzene;2,4-dimethoxybenzyl chloride;Benzene, 1-(chloromethyl)-2,4-dimethoxy-;SCHEMBL590943;DTXSID20594254;BQBRGOQCWAXXLR-UHFFFAOYSA-N;MFCD09745131;AKOS000262024;DA-04892;A8055;1-(Chloromethyl)-2,4-dimethoxy-benzene, 0.5M in THF

Suppliers and Price of 1-(Chloromethyl)-2,4-dimethoxybenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(CHLOROMETHYL)-2,4-DIMETHOXYBENZENE 95.00%
5MG
$ 504.03

Alichem
2,4-Dimethoxybenzylchloride
1g
$ 1490.00

Alichem
2,4-Dimethoxybenzylchloride
500mg
$ 782.40

Alichem
2,4-Dimethoxybenzylchloride
250mg
$ 499.20

Total 25 raw suppliers

Chemical Property of 1-(Chloromethyl)-2,4-dimethoxybenzene

Chemical Property:

Vapor Pressure:0.013mmHg at 25°C
Refractive Index:1.51
Boiling Point:268.422 °C at 760 mmHg
Flash Point:104.401 °C
PSA：18.46000
Density:1.13 g/cm³
LogP:2.44260
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:186.0447573
Heavy Atom Count:12
Complexity:130

Purity/Quality:

97% ^*data from raw suppliers

1-(CHLOROMETHYL)-2,4-DIMETHOXYBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)CCl)OC

Technology Process of 1-(Chloromethyl)-2,4-dimethoxybenzene

There total 2 articles about 1-(Chloromethyl)-2,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

: 55791-52-1
1-(chloromethyl)-2,4-dimethoxybenzene

Guidance literature:: With pyridine; thionyl chloride; In dichloromethane; at -15 - -5 ℃;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 55791-52-1
1-(chloromethyl)-2,4-dimethoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0 °C / Inert atmosphere

2: thionyl chloride; pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;
DOI:10.1021/acs.orglett.5b00106

Reference yield: 99.0%

: 55791-52-1
1-(chloromethyl)-2,4-dimethoxybenzene

: 121134-54-1
1-iodo-2-(3-methylbut-3-en-1-yl)benzene

: (R)-1-(2,4-dimethoxyphenethyl)-1-methyl-2,3-dihydro-1H-indene

Guidance literature:: With nickel(II) bromide diethylene glycol dimethyl ether; (R)-4-(tert-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole; zinc; In N,N-dimethyl acetamide; at 40 ℃; for 16h; enantioselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.orglett.0c00688