7314-44-5

Basic information

• Product Name: 2,4-Dimethoxybenzyl alcohol
• Synonyms: 2,4-DIMETHOXYBENZYL ALCOHOL;(2,4-DIMETHOXYPHENYL)METHANOL;RARECHEM AL BD 0025;2,4-Dimethoxybenzyl;2,4-Dimethoxybenzenemethanol;2,4-Dimethoxybenzyl alcohol,99%;2,4-DiMethoxybenzyl alcohol, 99% 25GR;1-hydroxyMethyl-2,4-diMethoxybenzene
• CAS NO: 7314-44-5
• Molecular Formula: C₉H₁₂O₃
• Molecular Weight: 168.19
• EINECS: 230-775-2
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 7314-44-5.mol
• Article Data: 30

Chemical Properties

• Melting Point: 38-40 °C(lit.)
• Boiling Point: 177-179 °C10 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /Low Melting Solid
• Density: 1.1322 (rough estimate)
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.545-1.548
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.18±0.10(Predicted)
• Water Solubility: Soluble in alcohol. Insoluble in water.
• BRN: 2091660
• CAS DataBase Reference: 2,4-Dimethoxybenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxybenzyl alcohol(7314-44-5)
• EPA Substance Registry System: 2,4-Dimethoxybenzyl alcohol(7314-44-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36/37-26
• WGK Germany: 3
• Hazardous Substances Data: 7314-44-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

Uses

2, 4-Dimethoxybenzyl alcohol is used as a medical intermediate.

General Description

2,4-Dimethoxybenzyl alcohol reacts with trifluoroacetic acid to yield calix[4]resorcinarene octamethyl ether, which on demethylation and acetylation yields the derived octa-acetate.

InChI:InChI=1/C9H12O3/c1-11-8-4-3-7(6-10)9(5-8)12-2/h3-5,10H,6H2,1-2H3

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 53088-00-9 2-phenyl-2,3-dihydro-1H-benzoimidazole 
• 2150-41-6 methyl 2, 4-dimethoxybenzoate 
• 89-86-1 4-hydroxysalicylic acid 
• 98-85-1 1-Phenylethanol 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 67-63-0 isopropyl alcohol 
• 67-56-1 methanol 

Downstream Products

• 130716-94-8 4-(2-cyano-2-methylethyl)-2-methoxybenzyl alcohol 
• 187979-64-2 (2,4-dimethoxyphenyl)methyl methanesulfonate 
• 604-84-2 phenanthrene-9,10-diol 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 258875-95-5 2,4-dimethoxybenzyl 4-methoxyphenylacetate 
• 55791-52-1 1-(chloromethyl)-2,4-dimethoxybenzene 
• 215607-30-0 O-(2,4-dimethoxybenzyl)-N-(2,4,6-trimethoxybenzyl)hydroxylamine 
• 216067-75-3 N-(2,4-dimethoxy-benzyloxy)-3-(4-phenoxy-phenylsulfamoyl)-N-(2,4,6-trimethoxy-benzyl)-propionamide 
• 216067-77-5 N-(2,4-dimethoxy-benzyloxy)-3-[(naphthalen-1-ylmethyl)-sulfamoyl]-N-(2,4,6-trimethoxy-benzyl)-propionamide 
• 221675-79-2 2,4-dimethoxybenzyl 2,2-dimethyl-3-(diphenylphosphatoxy)dihydrocinnamate 
• 221675-83-8 2,4-dimethoxybenzyl 2,2-dimethyl-3-(diethylphosphatoxy)dihydro-p-methoxycinnamate 
• 221675-80-5 2,4-dimethoxybenzyl 2,2-dimethyl-3-(diethylphosphatoxy)dihydrocinnamate 
• 221675-77-0 2,4-dimethoxybenzyl 3-hydroxy-2,2-dimethyldihydrocinnamate 
• 258876-12-9 2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate 

Relevant articles and documents

High yield synthesis of the parent C-unsubstituted calix[4]resorcinarene octamethyl ether

Treatment of 2,4-dimethoxybenzyl alcohol with trifluoroacetic acid (TFA, 5% in CHCl3) affords, in almost quantitative yield calix[4]resorcinarene octamethyl ether, which on demethylation and acetylation yields the derived octa-acetate.

Synthesis of acyclic and cyclic phosphonates based on substituted 2-hydroxybenzylic alcohols

A convenient synthesis of benzylic phosphonates and 2,3-dihydrobenzo[d][1,2]oxaphosphole 2-oxides substituted at the aromatic ring, as well as their precursors, 2-hydroxybenzylic alcohols, from the derivatives of salicylic aldehyde, salicylic acid, and 2-hydroxyacetophenone bearing an additional hydroxy or methoxy group at the para position of the aromatic ring was developed. For the first time, the possibility of selective demethylation of the methoxy group positioned ortho to the methylene phosphonate fragment with retention of the methoxy group at the para position was shown.

Cobalt complex catalyzed atom-economical synthesis of quinoxaline, quinoline and 2-alkylaminoquinoline derivatives

A new phosphine-free Co(ii) complex-catalyzed synthesis of various quinoxalines via dehydrogenative coupling of vicinal diols with both o-phenylenediamines and 2-nitroanilines is reported. This complex was also effective for the synthesis of quinolines. The practical aspect of this catalytic system was revealed by the one-pot synthesis of 2-alkylaminoquinolines.