2-Chloropyrrole

Base Information

• Chemical Name: 2-Chloropyrrole
• CAS No.: 56454-22-9
• Molecular Formula: C4H4ClN
• Molecular Weight: 101.535
• Mol file: 56454-22-9.mol

Synonyms:Pyrrole,2-chloro- (1CI);2-Chloropyrrole;2-chloro-1H-pyrrole;

Chemical Property of 2-Chloropyrrole

Chemical Property:

• Melting Point: 79-81 °C
• Boiling Point: 181.225 °C at 760 mmHg
• PKA: 16.02±0.50(Predicted)
• Flash Point: 79.106 °C
• PSA: 15.79000
• Density: 1.274 g/cm³
• LogP: 1.66810

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-1H-pyrrole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloropyrrole

There total 7 articles about 2-Chloropyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

pyrrole (109-97-7,30604-81-0) → 2-chloropyrrole (56454-22-9) + 2,5-dichloropyrrole (56454-23-0) + 3-chloropyrrole (69624-11-9)

Guidance literature:

With N-chloroacetanilide; acetic acid; In dichloromethane; Product distribution; Ambient temperature; other solvents;

Reference yield:

1-chloro-1H-pyrrole (80263-41-8) → 2-chloropyrrole (56454-22-9) + 2,5-dichloropyrrole (56454-23-0) + pyrrole (109-97-7,30604-81-0) + 3-chloropyrrole (69624-11-9)

Guidance literature:

With methanol; In tetrachloromethane; for 2h; Product distribution; Heating; var. additives;

DOI:10.1021/jo00345a023

Reference yield:

pyrrole (109-97-7,30604-81-0) → 2-chloropyrrole (56454-22-9)

Guidance literature:

With sulfuryl dichloride; diethyl ether;

upstream raw materials:

pyrrole

1-chloro-1H-pyrrole

sulfuryl dichloride

Downstream raw materials:

2-benzoyl-5-chloropyrrole

5-chloro-1H-pyrrole-2-carboxaldehyde

Refernces

• 1、 Leen, Volker,Braeken, Els,Luckermans, Kristof,Jackers, Carine,Van Der Auweraer, Mark,Boens, Noel,Dehaen, Wim. "A versatile, modular synthesis of monofunctionalized BODIPY dyes". supporting information; experimental part. p. 4515 - 4517. Retrieved 2010/01/06.
• 2、 Zhang, Yanhua,Shibatomi, Kazutaka,Yamamoto, Hisashi. "Lewis acid catalyzed highly selective halogenation of aromatic compounds". . p. 2837 - 2842. Retrieved 2007/10/03.