Technology Process of 2-(4-(pyrrolidin-1-yl)phenyl)pyrano[3,2-g]indol-4(9H)-one
There total 10 articles about 2-(4-(pyrrolidin-1-yl)phenyl)pyrano[3,2-g]indol-4(9H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4'-N-pyrrolidino-benzoyl methyl ketone;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -20 ℃;
for 1h;
7-methoxy-1H-indole-6-carbonyl chloride;
With
oxalyl dichloride;
In
tetrahydrofuran;
at -20 ℃;
for 1h;
With
hydrogen bromide;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; nitric acid / 2 h / 0 °C
2.1: N,N-dimethyl-formamide / 120 °C
3.1: hydrogen; palladium(II) hydroxide / methanol / 20 °C
4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / Reflux
5.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C
6.2: -20 - 20 °C
7.1: hydrogen bromide / 3 h / Reflux
With
oxalyl dichloride; sulfuric acid; water; hydrogen bromide; hydrogen; nitric acid; palladium(II) hydroxide; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm301099x
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: N-chloro-succinimide / 20 °C
3.1: sulfuric acid; nitric acid / 2 h / 0 °C
4.1: N,N-dimethyl-formamide / 120 °C
5.1: hydrogen; palladium(II) hydroxide / methanol / 20 °C
6.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / Reflux
7.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C
8.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C
8.2: -20 - 20 °C
9.1: hydrogen bromide / 3 h / Reflux
With
N-chloro-succinimide; oxalyl dichloride; sulfuric acid; water; hydrogen bromide; hydrogen; nitric acid; palladium(II) hydroxide; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm301099x
