N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine

Base Information

• Chemical Name: N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine
• CAS No.: 883564-64-5
• Molecular Formula: C₂₂H₁₅BrN₄O₂
• Molecular Weight: 447.291
• Mol file: 883564-64-5.mol

Synonyms:N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine

Chemical Property of N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine

There total 6 articles about N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-hydrazino-3-(p-bromophenyl)-1,8-naphthyridine (883564-51-0) + 2H-benzo[d]1,3-dioxolane-4-carbaldehyde (7797-83-3) → N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine (883564-64-5)

Guidance literature:

With N,N-dimethyl-formamide; for 0.025h; microwave irradiation;

Reference yield:

2-chloro-3-(p-bromophenyl)-1,8-naphthyridine (883564-49-6) → N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine (883564-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / N₂H₄*H₂O / ethanol / 4 h / Heating

2: 96 percent / DMF / 0.03 h / microwave irradiation

With hydrazine hydrate; N,N-dimethyl-formamide; In ethanol;

Reference yield:

2-amino-3-(p-bromophenyl)-1,8-naphthyridine (883564-47-4) → N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine (883564-64-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / NaNO₂; aq. HCl / 0.5 h / 20 °C

2: 92 percent / POCl₃ / 0.03 h / microwave irradiation

3: 90 percent / N₂H₄*H₂O / ethanol / 4 h / Heating

4: 96 percent / DMF / 0.03 h / microwave irradiation

With hydrogenchloride; hydrazine hydrate; N,N-dimethyl-formamide; sodium nitrite; trichlorophosphate; In ethanol;

upstream raw materials:

2-hydrazino-3-(p-bromophenyl)-1,8-naphthyridine

2H-benzo[d]1,3-dioxolane-4-carbaldehyde

2-chloro-3-(p-bromophenyl)-1,8-naphthyridine

2-amino-3-(p-bromophenyl)-1,8-naphthyridine