7797-83-3

Usage

Chemical Properties

White to yellow solid

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 2461, 1991 DOI: 10.1016/S0040-4039(00)74353-X

Hazard

A poison by ingestion.

InChI:InChI=1/C8H6O3/c9-4-6-2-1-3-7-8(6)11-5-10-7/h1-4H,5H2

Upstream product

• 161886-19-7 benzo[1,3]dioxole-4-carbonitrile 
• 74-97-5 chlorobromomethane 
• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 74-95-3 1,1-dibromomethane 
• 249636-72-4 5-iodobenzo[d][1,3]dioxole-4-carbaldehyde 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 67-66-3 chloroform 
• 5876-51-7 5-iodo-1,3-benzodioxole 
• 769-30-2 benzo[1,3]dioxol-4-yl-methanol 
• 75-11-6 diiodomethane 
• 75-09-2 dichloromethane 
• 1634-04-4 tert-butyl methyl ether 
• 1521-38-6 2,3-dimethoxybenzoic acid 

Downstream Products

• 38489-70-2 2,3-(methylenedioxy)cinnamic acid 
• 769-30-2 benzo[1,3]dioxol-4-yl-methanol 
• 5768-39-8 benzo[1,3]dioxole-4-carboxylic acid 
• 28310-13-6 2,3-methylenedioxy-6-nitrobenzaldehyde 
• 69393-72-2 2H-benzo[d][1,3]dioxolan-4-ol 
• 883564-64-5 N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine 
• 67984-81-0 2,3-dihydroxybenzonitrile 
• 113557-34-9 2-bromo-4,5-dimethoxy-N-(2,3-methylenedioxybenzyl)phenethylamine 
• 113557-42-9 2-(3,4-dimethoxyphenethyl)-7,8-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-3-one 

Relevant academic research and scientific papers

Synthesis of new substituted 7,12-dihydro-6,12- methanodibenzo[c,f]azocine-5-carboxylic acids containing a tetracyclic tetrahydroisoquinoline core structure

A convenient and simple protocol has been developed for the synthesis of a series of new tetracyclic tetrahydroisoquinoline derivatives, 7,12-dihydro-6,12-methanodibenzo[c,f]-azocine-5-carboxylic acids by three component Petasis reaction with the use of aminoacetaldehyde acetals bearing substituted benzyl groups as the amine components followed by Pomeranz-Fritsch double cyclization reaction. By applying this method, several acids have been prepared in satisfactory yields. An unprecedented chemical behavior of a Petasis reaction product in diluted HCl solution leading to the formation of a phenylglycine derivative has been observed and the mechanism explaining such reactivity has been proposed.

Imidazo ring PAR4 antagonist and medical applications thereof

The invention relates to an imidazo ring compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt or ester or solvate thereof. The compound disclosed by the inventioncan be used for preparing medicines for preventing or treating thromboembolic diseases.

TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

Novel use of amine compounds

The invention provides a preparation method and novel use of amine compounds. Specifically, the invention provides compounds shown in the formula A or their optical isomers, racemes, solvates or pharmaceutically acceptable salts and a medical use thereof. The above compounds can be used for preparation of a pharmaceutical composition or a preparation. The pharmaceutical composition or preparationis used for (a) inhibiting a transient receptor potential channel protein TRPA1 and (b) treating diseases associated with the transient receptor potential channel protein, wherein each group is defined in the specification.

Modulators of protease activated receptors

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.

Synthesis and characterization of a Ni nanoparticle stabilized on Ionic liquid-functionalized magnetic Silica nanoparticles for tandem oxidative reaction of primary alcohols

In this research, preparation of the magnetic nanoparticle, coating by a silica shell using (3-aminopropyl) triethoxysilane and synthesis of a novel sulfonic acid-substituted imidazolium-based ionic liquid onto the surface of these particles via a multi-component reaction, is described. The functionalized nanoparticles was loaded by Ni nanoparticles and characterized by means of techniques such as XRD, FTIR, SEM, EDX, TEM, TGA and ICP-OES. The nanostructures have spherical shapes that ranged in size from 80 to 100?nm. The catalytic activity of these nanoparticles was tested in aerobic oxidation of primary alcohols that showed good performance in the wide range of primary alcohols in water at mild reaction conditions. As a second step of this work, the tandem oxidative synthesis of alkylacrylonitriles and bisindolylmethanes were investigated using primary alcohols under oxidation conditions. This catalyst system can be recovered using external magnet and reused for five consecutive cycles without significantly less of its activity.

Acceptorless Dehydrogenation of Alcohols Catalyzed by CuI N-Heterocycle Thiolate Complexes

CuI N-heterocycle thiolate clusters efficiently catalyze the acceptorless dehydrogenation of alcohols at 70 °C. A variety of secondary/primary benzylic, allylic, and aliphatic alcohols are dehydrogenated to the corresponding ketones and aldehydes in high yields of isolated product upon release of H2. This simple catalytic system is involved in the synthesis of imines through the one-pot reaction of alcohols and amines.

NEW PYRIDOPYRIMIDINES DERIVATIVES COMPOUNDS

The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.

Platinum nanoparticles supported on polymeric ionic liquid functionalized magnetic silica: effective and reusable heterogeneous catalysts for the selective oxidation of alcohols in water

In this research, the syntheses of core-shell magnetic silica nanostructures, functionalized by a polymeric ionic liquid and immobilization of platinum nanoparticles, are described. Firstly, the magnetic silica nanoparticles were synthesized and modified using an amine-containing organosilane through a single-step process. The synthesized nanostructures were functionalized by the synthesis and polymerization of a pyridinium ionic liquid and a methyl methacrylate monomer, respectively, onto their surfaces. The platinum nanoparticles were immobilized on the functionalized nanoparticles. The obtained functionalized nanostructures have been used in the selective aerobic oxidation, in an aqueous medium, of primary and encumbered secondary aliphatic alcohols, and exhibit high activity at mild temperatures.

Synthesis and properties of bimetallic Hoveyda-Grubbs metathesis catalysts

The catalytic activity of ruthenium Hoveyda-Grubbs complexes in olefin metathesis is a function of complex steric and electronic effects acting on initiation and propagation steps. In order to study the π-electron factors influencing the initiation process, we attempted syntheses of bimetallic complexes with common organic ligands bearing two chelate rings. While most of the studied ligand exchange reactions of the isomeric bis-chelating benzene derivatives gave mixtures of unstable complexes, a homodinuclear derivative of 1,4-dimethoxy-2,5-divinylbenzene was sparingly soluble and precipitated from the reaction mixture in a pure form. The complex was studied with spectroscopic and X-ray methods, which confirmed the symmetrical bimetallic structure. However, in model metathesis reactions the catalyst displayed activity very comparable to the related monometallic complexes. This suggests that in the bimetallic system two consecutive initiation processes of the metathesis catalyst (first, bimetallic complex + olefin → monometallic complex + propagating species; second, monometallic complex + olefin → styrene + propagating species) proceed at similar rates and, thus, no cooperativity between the two steps is displayed. Properties of the family of bimetallic complexes were probed with NMR studies, and π-electronic effects operating in the systems were discussed.