N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride

Base Information

Chemical Name:N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride
CAS No.:1351672-22-4
Molecular Formula:C₂₁H₂₉F₄N₃O₃S*ClH
Molecular Weight:516
Hs Code.:

Synonyms:N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride

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Chemical Property of N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride

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Technology Process of N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride

There total 5 articles about N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1351674-84-4
N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

: 1351672-22-4
N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In water; acetonitrile; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00914

Reference yield:

: 4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexanecarbonitrile

: 1351672-22-4
N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 12 h / 25 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 25 °C / Inert atmosphere

3: hydrogenchloride / water; acetonitrile / 0.5 h / 25 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00914

Reference yield:

: 913952-86-0
tert-butyl 4-(propylsulfonyl)piperazine-1-carboxylate

: 1351672-22-4
N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 16 h / 25 °C / Inert atmosphere

2.1: titanium(IV) isopropylate / toluene / 2 h / 25 °C / Inert atmosphere

2.2: 16 h / 25 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 12 h / 25 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 4 h / 25 °C / Inert atmosphere

5.1: hydrogenchloride / water; acetonitrile / 0.5 h / 25 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; lithium aluminium tetrahydride; triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00914