N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

Base Information

Chemical Name:N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide
CAS No.:1351674-84-4
Molecular Formula:C₂₁H₂₉F₄N₃O₃S
Molecular Weight:479.539
Hs Code.:

Synonyms:N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

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Chemical Property of N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

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Technology Process of N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

There total 3 articles about N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913952-86-0
tert-butyl 4-(propylsulfonyl)piperazine-1-carboxylate

: 1351674-84-4
N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 16 h / 25 °C / Inert atmosphere

2.1: titanium(IV) isopropylate / toluene / 2 h / 25 °C / Inert atmosphere

2.2: 16 h / 25 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 12 h / 25 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 4 h / 25 °C / Inert atmosphere

With titanium(IV) isopropylate; lithium aluminium tetrahydride; triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.6b00914

Reference yield:

: 505068-18-8
1-(propylsulfonyl)piperazine

: 1351674-84-4
N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate / toluene / 2 h / 25 °C / Inert atmosphere

1.2: 16 h / 25 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 12 h / 25 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 4 h / 25 °C / Inert atmosphere

With titanium(IV) isopropylate; lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.6b00914

Reference yield:

: 4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexanecarbonitrile

: 1351674-84-4
N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 12 h / 25 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/acs.jmedchem.6b00914