Technology Process of 4-[8-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-benzoic acid
There total 8 articles about 4-[8-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C21H18N4O3;
With
lithium hydroxide;
In
acetone;
at 20 - 70 ℃;
With
hydrogenchloride;
In
water; acetone;
pH=1;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dmap / pyridine
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / tetrahydrofuran / 100 °C
3: trifluoroacetic acid
4: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C
5: sodium hydroxide / water / 85 °C
With
dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; pyridine; water;
DOI:10.1016/j.bmcl.2013.06.008
- Guidance literature:
-
Multi-step reaction with 4 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / tetrahydrofuran / 100 °C
2: trifluoroacetic acid
3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C
4: sodium hydroxide / water / 85 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/j.bmcl.2013.06.008
