1124382-72-4

Usage

Uses

Used in Pharmaceutical Research:
8-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine is used as a research compound for the development of new drugs, leveraging its ability to interact with biological targets and potentially modulate various biological pathways.
Used in Drug Development:
In the pharmaceutical industry, 8-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine is utilized as a key intermediate in the synthesis of novel therapeutic agents, contributing to the advancement of medicinal chemistry and the discovery of innovative treatments for various diseases.
It is important to handle 8-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine with care, as it may possess hazardous properties. Proper safety precautions should be taken when working with this chemical in laboratory settings to ensure the well-being of researchers and the integrity of the experiments.

Upstream product

• 1124383-00-1 N-(3-bromo-2-pyridinyl)-N’-carboethoxy-thiourea 
• 13534-99-1 2-Amino-3-bromopyridine 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 

Downstream Products

• 1319068-99-9 8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 
• 1257704-11-2 [8-(2-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-phenylamine 
• 1257704-27-0 [8-(3-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-phenylamine 
• 1257704-14-5 [8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-phenylamine 
• 1257705-65-9 (3-methanesulfonylphenyl)-[8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amine 
• 1257705-64-8 (4-methanesulfonylphenyl)-[8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amine 
• 1257704-47-4 [8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(3-morpholin-4-yl-phenyl)amine 
• 1257704-12-3 [8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(4-morpholin-4-yl-phenyl)amine 
• 1257704-57-6 {[8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]-pyridin-2-yl]-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine} 
• 1257704-52-1 [8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(4-methylpiperazin-1-yl)phenyl]amine 
• 1257705-68-2 [8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[3-(4-methylpiperazin-1-ylmethyl)phenyl]amine 
• 1257705-72-8 N-{3-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}-8-[4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine 
• 1257704-86-1 [8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[3-(4-morpholin-4-ylpiperidin-1-yl)phenyl]amine 
• 1257704-88-3 [8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-{3-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amine 

Relevant academic research and scientific papers

TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE

The present invention relates to triazolo pyridines of formula (II) and their use as modulators of ?-secretase. In particular, the present invention relates to compounds which interfere with ?-secretase and/or its substrate and therefore modulate the form

ORGANIC COMPOUNDS AND ORGANIC ELECTRO LUMINESCENCE DEVICE COMPRISING THE SAME

The present invention relates to a novel compound and an organic electroluminescent device comprising the same. A compound according to the present invention is used for an organic layer, preferably a light emitting layer of the organic electroluminescent

Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators

The identification and optimization of a novel series of centrally efficacious gamma secretase modulators (GSMs) offering an alternative to the privileged aryl imidazole motif is described. Chiral bicyclic tetrahydroindazolyl amine substituted triazolopyr

NOVEL COMPOUNDS AND ORGANIC ELECTRO LUMINESCENCE DEVICE USING THE SAME

The present invention relates to a novel compound and to an organic electroluminescent device comprising same. The compound according to the present invention is used in an organic layer, and more preferably, in a light-emitting layer of the organic elect

An Improved Synthesis of the Free Base and Diglycolate Salt of CEP-33779; A Janus Kinase 2 Inhibitor

CEP-33779 is a triazole that has been reported to show highly selective inhibition of Janus kinase 2 (JAK2). An efficient process to form CEP-33779 will be presented that uses multiple palladium couplings to provide the drug substance in a convergent mann

JANUS KINASE 2 (JAK2) INHIBITOR FOR THE TREATMENT OF LUPUS

The present invention provides a method for treating lupus in a subject, comprising the step of administering to the subject COMPOUND A.

ORGANIC COMPOUNDS AND ORGANIC ELECTRO LUMINESCENCE DEVICE COMPRISING THE SAME

The present invention relates to novel compounds and an organic electroluminescent device comprising the same. According to the present invention, the compounds can improve light emitting efficiency, driving voltage, life span, etc. of the organic electroluminescent device by being used in an organic layer, desirably a light emitting layer of the organic electroluminescent device. The compounds are represented by chemical formula 1.COPYRIGHT KIPO 2015

NOVEL SUBSTITUTED INDOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted indole derivatives of Formula (I) wherein R1, R2, R3, A1, A2, A3, Y and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators

The evolution of amide 3 into conformationally restricted bicyclic triazolo-piperidine 14-S as a γ-secretase modulator is described. This is a potential disease modifying anti-Alzheimer's drug which demonstrated high in vitro and in vivo potency against Aβ42 peptide, reduced lipophilicity and enhanced brain free fraction compared to the previous series.

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1, 5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed.