(4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid

Base Information

• Chemical Name: (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid
• CAS No.: 742676-98-8
• Molecular Formula: C₁₉H₂₀ClNO₆S
• Molecular Weight: 425.89
• Mol file: 742676-98-8.mol

Synonyms:(4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid

Chemical Property of (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid

There total 5 articles about (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

bromomethanesulfonic acid,sodium salt (34239-78-6) + (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one (176495-23-1) → (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid (742676-98-8)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 135 ℃;

DOI:10.1016/S0960-894X(97)00266-7

Reference yield:

(R)-(-)-p-methoxyamphetamine (58993-79-6,23239-32-9) → (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid (742676-98-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) AcNHTMS, 2.) aq. HCl / 1.) 110 deg C, 2.) EtOAc, 0 deg C to room temp.

2: 90 percent / Et₃N / CHCl₃ / Ambient temperature

3: 81 percent / BBr₃ / CH₂Cl₂ / 0 °C

4: 62 percent / NaOH / dimethylformamide / 135 °C

With hydrogenchloride; sodium hydroxide; boron tribromide; triethylamine; N-Trimethylsilylacetamide; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00266-7

Reference yield:

(R)-meta-chlorostyrene oxide (20697-04-5,53631-04-2,115648-90-3,62600-71-9) → (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid (742676-98-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) AcNHTMS, 2.) aq. HCl / 1.) 110 deg C, 2.) EtOAc, 0 deg C to room temp.

2: 90 percent / Et₃N / CHCl₃ / Ambient temperature

3: 81 percent / BBr₃ / CH₂Cl₂ / 0 °C

4: 62 percent / NaOH / dimethylformamide / 135 °C

With hydrogenchloride; sodium hydroxide; boron tribromide; triethylamine; N-Trimethylsilylacetamide; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00266-7

upstream raw materials:

bromomethanesulfonic acid,sodium salt

(R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one

(R)-(-)-p-methoxyamphetamine

(R)-meta-chlorostyrene oxide