1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Base Information

Chemical Name:1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid
CAS No.:1361293-70-0
Molecular Formula:C₃₅H₄₂ClNO₇Si
Molecular Weight:652.259
Hs Code.:

1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Synonyms:1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

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Chemical Property of 1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

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Technology Process of 1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

There total 4 articles about 1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 18800-26-5
1-(2-bromoethoxy)-2-chlorobenzene

: 1361293-43-7
Ethyl 3-((benzyloxycarbonyl)(3-ethoxy-3-oxopropyl)amino)-4-(tert-butyldimethylsilyloxy)butanoate

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1361293-70-0
1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

: 1361293-69-7
1-benzyloxycarbonyl-2-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Guidance literature:: Ethyl 3-((benzyloxycarbonyl)(3-ethoxy-3-oxopropyl)amino)-4-(tert-butyldimethylsilyloxy)butanoate; With sodium; In ethanol; toluene; at 20 ℃; for 48h; Inert atmosphere;

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

N,N-phenylbistrifluoromethane-sulfonimide; 1-(2-bromoethoxy)-2-chlorobenzene; (p-hydroxyphenyl)boronic acid;

Reference yield:

: 102191-92-4
tert-butyldimethylsiloxyacetaldehyde

: 1361293-70-0
1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

: 1361293-69-7
1-benzyloxycarbonyl-2-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 5 h / 20 - 50 °C / Inert atmosphere

2.1: ethanol / 20 °C / Inert atmosphere; Reflux

3.1: sodium hydrogencarbonate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

4.1: sodium / toluene; ethanol / 48 h / 20 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

With sodium; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; toluene;

Reference yield:

: 94844-37-8
ethyl (2E)-4-{[tert-butyl(dimethyl)silyl]oxy}but-2-enoate

: 1361293-70-0
1-benzyloxycarbonyl-6-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

: 1361293-69-7
1-benzyloxycarbonyl-2-((tert-butyldimethylsilyloxy)methyl)-4-(4-(2-(2-chlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 20 °C / Inert atmosphere; Reflux

2.1: sodium hydrogencarbonate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

3.1: sodium / toluene; ethanol / 48 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

With sodium; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; toluene;