2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester

Base Information

Chemical Name:2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester
CAS No.:512196-75-7
Molecular Formula:C₁₉H₂₈O₄
Molecular Weight:320.429
Hs Code.:

Synonyms:2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester

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Chemical Property of 2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester

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Technology Process of 2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester

There total 6 articles about 2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 512197-06-7
2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-3-enoic acid tert-butyl ester

: 512196-75-7
2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; for 20h;
DOI:10.1021/ol0275264

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 512196-75-7
2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / potassium hydroxide / dimethylsulfoxide / 2 h / 0 °C

2.1: 97 percent / Jones reagent / acetone / 1.5 h

3.1: 57 percent / CH₂Cl₂ / 40 h / -20 - 20 °C

4.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 100 percent / tetrahydrofuran; hexane / 2.5 h / -78 °C

5.1: 80 percent / pyridine; thionyl chloride / 1.5 h / -10 - 20 °C

6.1: 93 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 20 h

With pyridine; potassium hydroxide; thionyl chloride; jones reagent; potassium tert-butylate; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; acetone; tert-butyl alcohol; 2.1: Jones oxidation;
DOI:10.1021/ol0275264

Reference yield:

: 119649-45-5
4-(p-methoxybenzyloxy)butan-1-ol

: 512196-75-7
2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbut-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / Jones reagent / acetone / 1.5 h

2.1: 57 percent / CH₂Cl₂ / 40 h / -20 - 20 °C

3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 100 percent / tetrahydrofuran; hexane / 2.5 h / -78 °C

4.1: 80 percent / pyridine; thionyl chloride / 1.5 h / -10 - 20 °C

5.1: 93 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 20 h

With pyridine; thionyl chloride; jones reagent; potassium tert-butylate; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; acetone; tert-butyl alcohol; 1.1: Jones oxidation;
DOI:10.1021/ol0275264