trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester

Base Information

• Chemical Name: trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester
• CAS No.: 888701-44-8
• Molecular Formula: C₂₄H₁₈F₃NO₆S
• Molecular Weight: 505.471

Synonyms:trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester

Chemical Property of trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester

Chemical Property:

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Technology Process of trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester

There total 3 articles about trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxyphthalic anhydride (27550-59-0) → trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester (888701-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Heating

2: triethylamine / toluene / 20 °C

With triethylamine; In toluene;

DOI:10.1016/j.bmcl.2005.07.048

Reference yield:

2-((R)-2-Benzyloxy-1-phenyl-ethyl)-5-hydroxy-isoindole-1,3-dione (888701-05-1) + trifluoromethylsulfonic anhydride (358-23-6) → trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester (888701-44-8)

Guidance literature:

With triethylamine; In toluene; at 20 ℃;

DOI:10.1016/j.bmcl.2005.07.048 DOI:10.1016/j.bmc.2006.07.008

Reference yield:

4-hydroxyphthalic acid (610-35-5) → trifluoro-methanesulfonic acid 2-(2-benzyloxy-1-phenyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl ester (888701-44-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Heating

2: Heating

3: triethylamine / toluene / 20 °C

With triethylamine; In toluene;

DOI:10.1016/j.bmcl.2005.07.048

upstream raw materials:

2-((R)-2-Benzyloxy-1-phenyl-ethyl)-5-hydroxy-isoindole-1,3-dione

trifluoromethylsulfonic anhydride

4-hydroxyphthalic anhydride

4-hydroxyphthalic acid

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