3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid

Base Information

• Chemical Name: 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid
• CAS No.: 1256350-54-5
• Molecular Formula: C₂₅H₂₂O₇
• Molecular Weight: 434.445
• Mol file: 1256350-54-5.mol

Synonyms:3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid

Chemical Property of 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid

There total 23 articles about 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carbaldehyde → 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid (1256350-54-5)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; at 20 - 40 ℃; for 1h;

DOI:10.3762/bjoc.12.266

Reference yield: 100.0%

methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate (1180491-74-0) → 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid (1256350-54-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 16h;

DOI:10.1021/ol102322g

Reference yield: 17.0%

2-(1-(3,5-Dimethoxyphenyl)-2-(4-methoxyphenyl)-2-oxoethyl)-3,5-dimethoxybenzoic acid → 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid (1256350-54-5) + 4-(3,5-Dimethoxyphenyl)-5,7-dimethoxy-3-(4-methoxyphenyl)-1H-isochromen-1-one

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 1h;

DOI:10.1021/acs.joc.7b03089

upstream raw materials:

methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate

2-iodo-3,5-dimethoxybenzyl acetate

2-iodo-3,5-bis(methoxy)benzenemethanol

3,5-dimethoxybenzyl alcohol

Downstream raw materials:

4,7,9-trihydroxy-1-(4-hydroxyphenyl)-6H-anthra[1,9-bc]furan-6-one

4,7,9-trimethoxy-1-(4-methoxyphenyl)-6H-anthra[1,9-bc]furan-6-one